Table 5.
Comparison of median fecal bile acid values pre and post rifaximin
Median values in μg/100 mg dry stool | Prospective trial | |
---|---|---|
Pre rifaximin (n=6) | Post-rifaximin (n=6) | |
Total Bile Acids | 581 | 526 |
Primary | ||
CA | 21.5 | 39.3* |
CDCA | 2.6 | 19.2* |
Secondary | ||
LCA | 113.9 | 118.9 |
DCA | 377.6 | 354.2 |
Secondary/Primary Ratios | ||
LCA/CDCA | 20.1 | 3.4* |
DCA/CA | 13.9 | 2.5 |
LCA+DCA / CDCA+CA | 17.5 | 2.5* |
p<0.05 in this open-label trial of rifaximin in early cirrhotic patients, there was a net decrease in the secondary/primary BA ratio after rifaximin using the Wilcoxon matched-pairs test.
CA: cholic acid, CDCA: chenodeoxycholic acid, LCA: lithocholic acid, DCA: deoxycholic acid