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. 2014 Mar;184(3):800–807. doi: 10.1016/j.ajpath.2013.11.013

Figure 3.

Figure 3

Ultrastructural details of giant axons in spinal cord and sciatic nerve. A: Giant axon with an extremely attenuated myelin sheath in the anterior column of the spinal cord (Kel−/−Xk−/−). B: Giant axon with an extremely attenuated myelin sheath in the sciatic nerve (Xk−/−). C: Giant axon with irregular accumulation of NFs and apparent absence of other organelles in the sciatic nerve (Xk−/−). D: Giant axon with a thin myelin sheath containing irregularly arranged NFs and sparsely scattered microtubules in the anterior column of the spinal cord (Kel−/−Xk−/−). E: Segregation of microtubules from NFs on a cross section of the sciatic nerve (Kel−/−Xk−/−). F: Irregularly dispersed microtubules in the anterior column of the spinal cord (Kel−/−). G: Accumulation of dense lamellar bodies and membranous vesicles indicating axonal degeneration in the anterior column of the spinal cord (Kel−/−Xk−/−). H: Membranous structures involving the adaxon of a Schwann cell in the anterior column of the spinal cord (Kel−/−). I: Atrophic axon with contracted axon surrounded by a thick myelin sheath containing osmium-dense particles in the sciatic nerve of Kel−/−Xk−/− mice. Symbols: opposing arrows, thin or absent MS; short black arrow or black star, NF; long black arrow, MV; black arrowhead or white star, MT; white arrow, DLB. Sections are 80 nm thick. Scale bars: 2 μm (A, B, and I); 500 nm (C–H). DLB, dense lamellar body; M, mitochondria; MS, myelin sheath; MT, microtubule; MV, membranous vesicles; SciN, sciatic nerve; SpAC, anterior column of the spinal cord.