Table 2.
Frequency of Giant Axons and/or Paranodal Demyelination in the Sciatic Nerve
| Genotype and condition | Older mice |
Younger mice |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases (no.) | Score∗ |
Cases (no.) | Score∗ |
|||||||
| − | + | ++ | +++ | − | + | ++ | +++ | |||
| Nonexercised | 17 months | 6–12 months | ||||||||
| WT | 7 | 6 | 1 | 0 | 0 | 4 | 4 | 0 | 0 | 0 |
| Xk−/− | 4 | 2 | 2 | 0 | 0 | 3 | 3 | 0 | 0 | 0 |
| Kel−/− | 2 | 1 | 0 | 1 | 0 | 3 | 3 | 0 | 0 | 0 |
| Kel−/−Xk−/− | 5 | 2 | 2 | 1 | 0 | 4 | 4 | 0 | 0 | 0 |
| Exercised | 16–19 months | 10 months | ||||||||
| WT | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| Xk−/− | 2 | 1 | 0 | 1 | 0 | 2 | 1 | 1 | 0 | 0 |
∗
Scoring as defined for Table 1, except based on one cross section of sciatic nerve.