Table 3.
HCC Subtypes Identified by Gene Expression Profiling Approaches
| Subtypes | Genes/Processes | Clinical endpoint | References |
|---|---|---|---|
| A and B | Multiple/proliferation | Overall survival | 61 |
| CIN: high and low | Proliferation | Overall survival | 64 |
| G1-G6 | Multiple/proliferation | Overall survival | 67 |
| RB-loss: high and low | Proliferation | Overall survival | 63 |
| A, B, and C | Multiple/proliferation | Overall survival | 65 |
| 65 genes | Multiple | Overall survival | 72 |
| 5-gene score | HN1, RAN, RAMP3, KRT19, and TAF9 | Overall survival End-stage disease |
70 |
| 186-gene signature | Nontumor liver | Overall survival Risk of recurrence |
69 |
CIN, chromosome instability signature.