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. 2014 Mar;184(3):827–841. doi: 10.1016/j.ajpath.2013.11.016

Figure 4.

Figure 4

Altered localization of hematopoietic stem/progenitor cells in Klotho−/− mice. Frequency of the HSC population stained for SLAM (CD150+ CD48−) (WT, n = 14; Klotho−/−, n = 14) (A), the Lin− Sca-1+ (C) Kit+ (LSK) HSC population (WT, n = 9; Klotho−/−, n = 7) (B), and the primitive c-Kit+Thy1+Lin−Sca 1+ (KTLS) HSC population (WT, n = 7; Klotho−/−, n = 7) (C) in the Klotho−/− BM compartment. D: Circulating SLAM (CD150+ CD48−) population in peripheral blood (PB) (WT, n = 7; Klotho−/−, n = 6). Retention of phenotypic SLAM (WT, n = 11; Klotho−/−, n = 8) (E), Lin− Sca-1+ c-Kit+ (LSK) (WT, n = 9; Klotho−/−, n = 9) (F), and primitive c-Kit+Thy1+Lin−Sca 1+ (KTLS) population (WT, n = 10; Klotho−/−, n = 9) (G) in splenocytes from Klotho−/− mice compared with their WT littermates. Data represent the means ± SEM. ∗P < 0.05 and ∗∗P < 0.01.