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. 2014 Mar;184(3):827–841. doi: 10.1016/j.ajpath.2013.11.016

Figure 5.

Figure 5

The perturbed in vitro and in vivo homing ability of Klotho−/− BM cells. A:In vitro migration experiment of the migratory capacity of Klotho−/− BM cells toward an SDF-1α gradient (WT, n = 5; Klotho−/−, n = 5). B: Flow cytometry of CXCR4 in Klotho−/− BM compared with WT mice (WT, n = 11; Klotho−/−, n = 8). C: SDF-1α concentration measured by ELISA in the serum of WT (n = 10) and Klotho−/− (n = 10) mice. Samples were measured in duplicate. D: Graphic representation of flow cytometry analysis of the BM, spleen, and peripheral blood after transplantation of WT (n = 8) or Klotho−/− (n = 8) BM cells in myeloablated B6.SJL recipient mice. E–G: Flow cytometry profiles of the peripheral blood, spleen, and BM after transplantation. SSC, side scatter. Data represent the means ± SEM. ∗P < 0.05 and ∗∗P < 0.01.