Figure 5. K7 Acetylation Marks Paused Polymerases.
(A) Graph showing the percentage of paused (pausing index cutoff = 3) genes per gene decile. Genes were sorted into deciles according to their occupancy by total or acetylated RPB1, with the lowest occupied genes in decile one and genes with the highest occupancies in decile ten.
(B) UCSC browser tracks (http://genome.ucsc.edu) for acetylated and total RPB1 at the entire c-Fos and Eif4a1 genes as well as just the TSS.
(C) Plots showing the acetylated and total RPB1 occupancy in counts per base pair at the TSS for paused and nonpaused genes.
(D) Plots showing the acetylated and total RPB1 center of mass distribution at the TSS for paused and nonpaused genes.