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. Author manuscript; available in PMC: 2014 Feb 26.
Published in final edited form as: J Mol Cell Cardiol. 2012 Jul 11;53(3):429–436. doi: 10.1016/j.yjmcc.2012.06.019

Fig 1. Effects of chronic CaMKII inhibition on frequency dependent LV contractility.

Fig 1

A. An example of LV pressure-frequency relation in wild type (WT) shows LV pressure increases after increase in pacing rate. B. An example of LV pressure-frequency relation in heart of Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibition (AC3-I) shows no significant increase of LV pressure after increase in pacing rate. C. Summary of left ventricular developed pressure (LVDP) at different pacing rates. D. LVDP at different pacing rates normalized by the LVDP at 6 Hz. E. Summary of maximum LV pressure change rate (dP/dt max) at different pacing rates. F. dP/dt max at different pacing rates normalized by the dP/dt max at 6 Hz. Data from 10 WT and 11 AC3-I isolated heart experiments. ## P<0.01, # P<0.05 vs WT; **P<0.01vs data at 6 Hz. ↓ Indicates where data was measured.