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. Author manuscript; available in PMC: 2014 Feb 26.
Published in final edited form as: J Mol Med (Berl). 2010 Jul 10;88(12):1195–1201. doi: 10.1007/s00109-010-0651-0

Fig. 2.

Fig. 2

Schematic illustration showing hypothalamic POMC processing. The polypeptide prohormone precursor POMC is cleaved by prohormone convertase 1 (PC1/3) in pro-ACTH and β-lipotrophin. PC1/3 will further cleave pro-ACTH to form ACTH1–39 which will be cleaved by prohormone convertase 2 (PC2) to form ACTH1–17. Carboxypeptidase E (CPE) and then α-amidating monooxygenase (PAM) will further process ACTH1–17 to form desacetyl α-MSH1–13. The acetylation of α-MSH1–13 by a n-acetyltransferase (NAT) not yet identified will then produce acetyl-α-MSH1–13. The action of acetyl-α-MSH1–13 will be finally ended by prolylcarboxypeptidase (PRCP) which will convert acetyl-α-MSH1–13 in the inactive product acetyl-α-MSH1–12