Fig. 1.

Curcumin inhibited IgE/Ag-induced PSA reaction. In the PSA test, ICR mice were sensitized by injecting 2 μg of IgE i.v. in 100 μl saline or injected with saline alone. 24 h later mice were administered 25 or 50 mg/kg of curcumin or 50 mg/kg fexofenadine-HCl (Fexo) and 1 h later were challenged with 4 mg of DNP-HSA i.v in 200 μl saline; blood was collected by cardiac puncture 5 min after the Ag challenge. The concentration of serum LTC₄ (A), PGD₂ (B), and histamine (C) were determined using appropriate enzyme immunoassay kits (Cayman Chemicals). The values indicate the mean ± S.D. from three independent experiments, ^**p<0.01 versus IgE/Ag sensitized mice). Fexo (50 mg/kg) was used as an anti-histamine control drug.