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(a) Structure of the de-esterified form of the neuraminidase inhibitor oseltamivir in complex with the H274Y mutant of influenza virus N1 neuraminidase that displays resistance to treatment with oseltamivir (PDBID 3CL0 [134]). (b) Schematic representations of the natural substrate (neuraminic acid). (c) Schematic representations of the inhibitor.
