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. Author manuscript; available in PMC: 2014 Feb 27.
Published in final edited form as: World J Hypertens. 2012 Aug 23;2(4):34–44. doi: 10.5494/wjh.v2.i4.34

Table 1.

Reactive oxygen species signaling pathways and Ang II-induced cardiovascular diseases

Disease Receptor(s) NAD(P)H oxidase ROS CaMKII Other signaling molecules Ref.
Arrhythmias AT1R/AT2R + (Nox2) + + Ca2+ handing, RyR, ICa,L, INa, INCX [23,71,74–85]
Cell death/heart failure AT1R ? + (p47phox) + + p38MARK [70,88–90]
I/R injury AT1R/AT2R + + ? Rac1 GTPase [91–98]
Hypertrophy AT1R + + +, ? Transcription factors [67,103–113]
Hypertension AT1R + (p22phox) + + Nitric oxide [114–122]

+: Involved; ?: Not clear; AT1R: Ang II type 1 receptor; AT2R: Ang II type 2 receptor; RyR: Ryanodine receptor; ICa,L: L-type calcium current; INa: Sodium current; INCX: Sodium-calcium exchange current; p38MARK: p38 mitogen-activated protein kinase.