Table 1.
Analyte recovery from plasma.
Analyte | Theoretical concentration (ng/mL) | Recovered concentration (ng/mL)* | Recovery (%) | CV (%) |
---|---|---|---|---|
Buprenorphine | 0.001 | 0.00096 ± 0.00011 | 96.4 | 11.8 |
0.1 | 0.0966 ± 0.0058 | 96.6 | 6.0 | |
10 | 10.4 ± 0.77 | 104 | 7.3 | |
Norbuprenorphine | 0.01 | 0.00815 ± 0.00064 | 81.5 | 7.9 |
0.3 | 0.247 ± 0.032 | 82.4 | 12.8 | |
10 | 10.9 ± 1.7 | 109 | 16.0 | |
Buprenorphine Glucuronide | 0.001 | 0.00092 ± 0.00012 | 92.5 | 12.4 |
0.1 | 0.098 ± 0.010 | 98.2 | 10.5 | |
10 | 9.45 ± 0.66 | 94.5 | 6.9 | |
Norbuprenorphine Glucuronide | 0.01 | 0.0068 ± 0.0006 | 68.4 | 8.7 |
0.3 | 0.252 ± 0.063 | 84.2 | 24.9 | |
10 | 8.04 ± 2.00 | 80.4 | 25.0 |
Mean ± SD (N = 3).