Fas expression in circulating monocytes correlates negatively with insulin sensitivity in obese patients
A Monocytes were isolated from whole human blood samples of lean and obese subjects and Fas mRNA expression was measured normalized to HPRT. n = 16–247. **p = 0.005 (Student's t-test). Error bars represent SEM.
B Monocytes were isolated from whole human blood samples and Fas mRNA expression was measured normalized to HPRT. ***p < 0.0001 (Student's t-test). NGT: normal glucose tolerance (men n = 61; women n = 70); T2D: type 2 diabetes (men n = 57; women n = 58). Error bars represent SEM.
C,D Monocyte Fas mRNA expression was determined as described above and correlated to HOMA-IR (C) and glucose disposal rate (GDR) (D). n = 200 (C) and n = 163 (D). Error bars represent SEM.
E Monocyte Fas mRNA expression was determined in obese patients before and 6 months after bariatric surgery (gastric sleeve resection; n = 14), ***p = 0.0002 (Student's t-test).