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. 2013 Nov 6;6(1):43–56. doi: 10.1002/emmm.201302962

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© 2014 The Authors.

This is an open access article under the terms of the Creative Commons Attribution License, 1 which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fas expression in circulating monocytes correlates negatively with insulin sensitivity in obese patients

A  Monocytes were isolated from whole human blood samples of lean and obese subjects and Fas mRNA expression was measured normalized to HPRT. n = 16–247. **p = 0.005 (Student's t-test). Error bars represent SEM.

B  Monocytes were isolated from whole human blood samples and Fas mRNA expression was measured normalized to HPRT. ***p < 0.0001 (Student's t-test). NGT: normal glucose tolerance (men n = 61; women n = 70); T2D: type 2 diabetes (men n = 57; women n = 58). Error bars represent SEM.

C,D  Monocyte Fas mRNA expression was determined as described above and correlated to HOMA-IR (C) and glucose disposal rate (GDR) (D). n = 200 (C) and n = 163 (D). Error bars represent SEM.

E  Monocyte Fas mRNA expression was determined in obese patients before and 6 months after bariatric surgery (gastric sleeve resection; n = 14), ***p = 0.0002 (Student's t-test).