Figure 2.
Bacterial containment and clearance is enhanced by A2MG-E microparticles reducing local and systemic inflammation during microbial sepsis.
Mice were subjected to CLP (see Materials and Methods for details) 1 h later treated with PBS (100 μl i.v.), A2MG-E MP (1 × 105 i.v.) or sA2MG (0.05 μg) and sacrificed at 12 h. Results A, C–E are mean ± s.e.m. A, C–E, n = 6 mice per group; B, n = 12 mice per group (*P < 0.05, **P < 0.01 versus PBS treated mice by one way ANOVA).
A Aerobic bacterial levels in peritoneal exudates and blood from CLP mice.
B Body temperature at 12 h following CLP.
C Peritoneal exudate leukocyte and neutrophil counts.
D Counts for trapped neutrophils in lungs, as determined by light microscopy, Ly6G staining and flow cytometry.
E Exudate cytokine levels as determined by multiplex array.