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. 2013 Dec 16;6(1):27–42. doi: 10.1002/emmm.201303503

Figure 4.

Figure 4

LRP1 mediates the protective actions of A2MG during microbial sepsis. Results are mean ± s.e.m., n = 10 mice per group (§P < 0.05 versus cMV treated mice; *P < 0.05, versus PBS mice; #P < 0.05, versus LRP1 KD A2M-E MP mice by one tailed log rank test).

A  Microvesicles (cMV; 106/mouse) or microvesicles containing A2MG (A2MG-MV 106/mouse) were administered i.v. 5-min prior to CLP (see Materials and Methods for details) and survival assessed over a 96 h interval.

B  Mice were transfected with either mock or LRP1 siRNA (LRP1 KD see Materials and Methods for details). After 48 h PBS or A2MG-E MP (1 × 105 i.v.) were administered i.v. 5 min prior to CLP.