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. 2013 Nov 4;6(1):141–154. doi: 10.1002/emmm.201202150

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© 2014 The Authors.

This is an open access article under the terms of the Creative Commons Attribution License, 1 which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Vaccine protection in a chinchilla model of otitis media.

A The BHN97 strain is capable of causing otitis media in chinchillas via intranasal administration as observed by recoverable bacterial colony forming units (CFUs) from the middle ear (A) following challenge.

B, C Following vaccination, a reduction in the number of culture positive ears in the vaccinated group compared to the mock animals was observed (B) as well as a significant reduction in recoverable CFUs from the middle ear at 7 days postchallenge (C). * = p < 0.05 by Mann–Whitney.