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. 2013 Nov 4;6(1):141–154. doi: 10.1002/emmm.201202150

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© 2014 The Authors.

This is an open access article under the terms of the Creative Commons Attribution License, 1 which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Vaccine protection against heterologous challenge. Mice (n = 20 per group, performed in duplicate) were mock-vaccinated with PBS (Mock) or vaccinated with PCV13 or a live attenuated vaccine deleted for FtsY on a type 19F background (BNH97ΔftsY).

A Mice were challenged with a bioluminescent version of S. pneumoniaestrain BNH54 (type 7F) and assessed by imaging for development of otitis media over 72 h (24 h time point is pictured).

B, C Quantification of the luminescent signal (B) and weight loss (C) observed in the animals further supported the observed protection. An asterisk (*) indicates a significant difference (p < 0.05) by Chi-squared test compared to the mock vaccinated group. PCV13 contains type 7F antigen, so this was a homologous challenge for the PCV13 group but a heterologous challenge for the BNH97ΔftsY group.