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. 2012 Nov 14;32(46):16181–16192. doi: 10.1523/JNEUROSCI.0228-12.2012

Figure 3.

Figure 3.

The degeneration is rescued by expressing dBACE. A, A GMR-GAL4; UAS-dBACERNAi fly shows the characteristic row of vacuoles in the lamina cortex (arrowheads). B, In flies overexpressing dBACE in photoreceptors we find vacuoles in the lamina neuropil (la n), which can extend into the lamina cortex, but not the characteristic row of vacuoles seen in the retinal (re) knockdown flies (A). C, Coexpressing UAS-dBACERNAi with UAS-dBACE reduced the vacuoles in the lamina neuropil and cortex to the level in controls (Table 1). D, dBACE2045 over the Df(2L)Exel7038 showing vacuoles in the lamina cortex (arrowheads) and neuropil (arrow). E, Expression of UAS-dBACE in dBACE2045/Df(2L)Exel7038 via elav-GAL4 reduces the degenerative phenotype although some vacuoles can still be found (arrow). F, Expressing dBACE with the dBACE5.4-GAL4 promoter construct rescued the phenotype in dBACE2045/Df(2L)Exel7038 flies. G, H, Quantification of the vacuoles in rescue flies versus dBACE knockdown flies (G) and point mutations (H). re, Retina. **p < 0.01, ***p < 0.001. All flies were 4 weeks old. Scale bar, 10 μm.