Figure 2.

Systemic artemin across 2 weeks immediately following injury restores neurochemical alterations in sensory fibers 6 weeks post- L₅ spinal nerve crush. Artemin treatment after nerve crush increased NF200, CGRP and IB4 labeled fibers observed in L₅ spinal nerve distal to crush region. Axotomy or nerve ligation of the L₅ spinal nerve greatly diminished NF200, CGRP and IB4 labeling in the spinal nerve distal to nerve injury. Labeling after L₅ ligation was sparse after artemin treatment, indicated by arrows, and labeling after axotomy was not affected by artemin treatment. Scale bar indicates 20 µm for all images.