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. Author manuscript; available in PMC: 2015 Mar 1.

Published in final edited form as: Pain. 2013 Nov 21;155(3):476–484. doi: 10.1016/j.pain.2013.11.007

Artemin promotes regeneration of non-myelinated and myelinated axons through nerve crush injury into sciatic nerve 6 weeks post L₅ spinal nerve crush. A. Artemin or vehicle treatment did not markedly change the number of cell bodies within the L₅ DRG showing retrograde labeling of dextran from sciatic nerve in sham-operated rats, corresponding to non-myelinated fibers. Artemin treatment increased dextran labeling in L₅ DRG of rats treated with nerve crush, but not in rats that had undergone axotomy or nerve ligation. Scale bar indicates 50 µm for all images. B. The graph shows quantification of dextran-labeled neurons from counted sections in percentages. Asterisks indicates significant differences (P < 0.05) compared to vehicle treatment with the same surgery. C. Artemin or vehicle treatment did not markedly change the number of cell bodies within the L₅ DRG showing retrograde labeling of CTB from sciatic nerve in sham-operated rats, corresponding to myelinated fibers. Artemin treatment increased CTB labeling in L₅ DRG of rats treated with nerve crush, but not in rats that had undergone axotomy or nerve ligation. Scale bar indicates 50 µm for all images. D. The graph shows quantification of CTB-labeled neurons from counted sections in percentages. Asterisks indicate significant differences (P < 0.05) compared to vehicle treatment with the same surgery.

Artemin promotes regeneration of non-myelinated and myelinated axons through nerve crush injury into sciatic nerve 6 weeks post L₅ spinal nerve crush. A. Artemin or vehicle treatment did not markedly change the number of cell bodies within the L₅ DRG showing retrograde labeling of dextran from sciatic nerve in sham-operated rats, corresponding to non-myelinated fibers. Artemin treatment increased dextran labeling in L₅ DRG of rats treated with nerve crush, but not in rats that had undergone axotomy or nerve ligation. Scale bar indicates 50 µm for all images. B. The graph shows quantification of dextran-labeled neurons from counted sections in percentages. Asterisks indicates significant differences (P < 0.05) compared to vehicle treatment with the same surgery. C. Artemin or vehicle treatment did not markedly change the number of cell bodies within the L₅ DRG showing retrograde labeling of CTB from sciatic nerve in sham-operated rats, corresponding to myelinated fibers. Artemin treatment increased CTB labeling in L₅ DRG of rats treated with nerve crush, but not in rats that had undergone axotomy or nerve ligation. Scale bar indicates 50 µm for all images. D. The graph shows quantification of CTB-labeled neurons from counted sections in percentages. Asterisks indicate significant differences (P < 0.05) compared to vehicle treatment with the same surgery.