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. Author manuscript; available in PMC: 2015 Mar 1.

Published in final edited form as: Pain. 2013 Nov 21;155(3):476–484. doi: 10.1016/j.pain.2013.11.007

Artemin promotes reinnervation by non-myelinated and myelinated fibers of peripheral cutaneous tissues. A. Rhodamine-dextran or CTB labeling in L₅ DRG 1 week following intradermal administration into the ipsilateral hindpaw, 6 weeks following sham or nerve crush. Artemin treatment did not alter rhodamine-dextran or CTB labeling in sham-operated rats. Artemin treatment increased rhodamine-dextran as well as CTB labeling in L₅ DRG of nerve crush treated rats compared to vehicle treated rats. Scale bar indicates 50 µm for all images. B. Quantification of rhodamine-dextran and CTB labeled neurons from L₅ DRG sections confirm an increase in the percentage of cells labeled for rhodamine-dextran or CTB with artemin treatment. Asterisks indicate significant differences (P < 0.05) compared to vehicle treatment after nerve crush.

Artemin promotes reinnervation by non-myelinated and myelinated fibers of peripheral cutaneous tissues. A. Rhodamine-dextran or CTB labeling in L₅ DRG 1 week following intradermal administration into the ipsilateral hindpaw, 6 weeks following sham or nerve crush. Artemin treatment did not alter rhodamine-dextran or CTB labeling in sham-operated rats. Artemin treatment increased rhodamine-dextran as well as CTB labeling in L₅ DRG of nerve crush treated rats compared to vehicle treated rats. Scale bar indicates 50 µm for all images. B. Quantification of rhodamine-dextran and CTB labeled neurons from L₅ DRG sections confirm an increase in the percentage of cells labeled for rhodamine-dextran or CTB with artemin treatment. Asterisks indicate significant differences (P < 0.05) compared to vehicle treatment after nerve crush.