. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: J Urol. 2013 May 10;191(1):220–226. doi: 10.1016/j.juro.2013.05.019

Table 4.

Performance Statistics for Secondary Selection Models of Upstaging.

Performance Statistics^*	AS Candidate Selection Model
	NCCN + TMPRSS2:ERG	NCCN + Secretion Capacity
Sensitivity	66.67 % (95% CI: 38.41 % to 88.05 %)	93.33 % (95% CI: 67.98 % to 98.89 %)
Specificity	84.08 % (95% CI: 78.27 % to 88.85 %)	55.72 % (95% CI: 48.56 % to 62.71 %)
Positive Predictive Value	23.81 % (95% CI: 12.07 % to 37.45 %)	13.59 % (95% CI: 7.64 % to 21.76 %)
Negative Predictive Value	97.13 % (95% CI: 93.42 % to 99.05 %)	99.12 % (95% CI: 95.15 % to 99.85 %)
5-fold cross validation	92.8% (95% CI: 91.3 to 94.3%)	92.9% (95% CI: 91.4 to 94.4%)

Parameters determined at ROC cutoff value for each model: 0.0961 for NCCN + TMPRSS2:ERG model, and 0.048 for the NCCN + Secretion Capacity Model.