Table 3.
Relative mRNA concentrations of genes associated with DNA damage, DNA repair and cell cycle in the liver of Holstein cows at 3 wk antepartum and 1, 5 and 14 wk postpartum 1
Gene 2 | 3 wk antepartum (n = 13) | 1 wk postpartum (n = 13) | 5 wk postpartum (n = 13) | 14 wk postpartum (n = 13) |
---|---|---|---|---|
ATM |
1.00 ± 0.21a |
2.29 ± 0.21b |
1.94 ± 0.35ab |
1.81 ± 0.26ab |
BRCA1 |
1.00 ± 0.22 |
1.71 ± 0.27 |
1.59 ± 0.20 |
1.33 ± 0.23 |
HSBP1 |
1.00 ± 0.23a |
3.04 ± 0.42b |
2.14 ± 0.24ab |
1.65 ± 0.34a |
HSPA8 |
1.00 ± 0.24a |
2.01 ± 0.24b |
1.78 ± 0.23ab |
1.22 ± 0.27a |
MSH2 |
1.00 ± 0.20a |
4.04 ± 0.61b |
1.81 ± 0.22a |
1.41 ± 0.23a |
RPS9 |
1.00 ± 0.20a |
3.68 ± 0.28c |
2.23 ± 0.29b |
1.64 ± 0.31ab |
XRCC5 | 1.00 ± 0.21a | 3.69 ± 0.54c | 2.35 ± 0.27b | 1.43 ± 0.26a |
1mRNA concentrations of genes are expressed relative to the mRNA abundance at 3 wk antepartum.
2ATM = ataxia telangiectasia mutated; BRCA1 = breast cancer 1, early onset; HSBP1 = heat shock factor binding protein 1; HSPA8 = heat shock 70 kDa protein 8; MSH2 = mutS homolog 2; RPS9 = ribosomal protein S9; XRCC5 = X-ray repair cross-complementing protein 5-like.
Values are means ± SEM.
a,b,cMeans without common superscripts differ significantly (P < 0.05).