Figure 4.

jRdRp-GTP interactions. The finger, thumb and palm domains are colored yellow, orange and cyan, respectively. GTP and the interacting amino acid residue are shown in stick representation. The water molecules responsible for water-mediated interactions between jRdRp and GTP are depicted in the form of red spheres. (A) The residues that interact with the triphosphate and sugar moieties of GTP are displayed. (B) The residues that form interactions with the guanine base and ribose sugar of GTP displayed. The base-specific hydrogen bonds formed between D541 and S604 with the N2 and O6 atoms of guanine are highlighted by dotted lines.