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. 2013 Nov 20;42(4):2483–2492. doi: 10.1093/nar/gkt1154

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — A preexisting spacer (spacer13) matching the HHPV-2 genome was required. (A) Depiction of the imperfect match between spacer13 and an HHPV-2 fragment. Positions of the fragment on the HHPV-2 genome are indicated under the sequence. Three upstream nucleotides corresponding to PAM motif are underlined. (B) Depiction of the spacer content of CRISPR variants. Δsp2–6, Δsp7–13, Δsp2–12, Δsp2–13 and Δsp1–14 are designated according to the spacers (or repeat) bordering the omitted region (dashed lines). In Δsp13, spacer13 and the immediately upstream repeat were deleted. (C) Adaptation of variant CRISPRs to HHPV-2 infection. Lane M, dsDNA size marker.