. Author manuscript; available in PMC: 2014 Jul 1.

Published in final edited form as: Ann N Y Acad Sci. 2013 Jul;1292:21–31. doi: 10.1111/nyas.12223

Table 1.

Comparison of ketamine- and magnesium-induced changes with reference to those observed in major depression

	Major depression (human)	Magnesium administration	Ketamine
PFC-NR1	⇔³⁹	⇔²⁶	⇑⁴⁰
PFC-NR2A	⇓³⁹	⇔²⁶	⇔⁴⁰
PFC-NR2B	⇓³⁹	⇑²⁶	⇑^40,41
Cortical (PFC)–GluR1	?	?	⇑^24,42 (after CUS)
Cortical (PFC)–GluR2	⇑⁴³	?	?
PFC–BNDF	?	⇑²⁶	⇑⁴⁴
PFC–PSD-95	⇓³⁹	?	⇑²⁴ (after CUS)
Cortical	⇓^45,46	⇑⁴⁷	⇑^44,48
P-CREB		⇔²⁶
PFC/ACC–glutamine/GS activity	⇓⁴⁶	⇑⁴⁹	⇑⁵⁰
Evoked synaptic potentials (cortex)	?	⇑²⁶	⇑²⁴ (after CUS)
Cortical synaptogenesis	?	⇑²⁶	⇑²⁴ (after CUS)

Adapted with permission from Ref. 11. CUS, chronic unpredictable stress.