Table 4.

Associations between severe OCs, perinatal asphyxia and brain structure volumes in patients with psychotic (n = 48) and non-psychotic (n = 31) BD ^a

	Severe OCs					Perinatal asphyxia
	t	p	adj p	B	(s.e.)	t	p	adj p	B	(s.e.)
Left hippocampus
Non-psychotic BD	−2.49	0.019	0.057	−386.2	(155.0)	−1.81	0.082	0.246	−333.2	(178.0)
Psychotic BD	−0.09	0.93	1	−11.0	(124.6)	−0.08	0.936	1	−12.3	(153.2)
Right hippocampus
Non-psychotic BD	−3.25	0.003	0.009	−485.6	(149.5)	−2.60	0.015	0.045	−449.0	(173.0)
Psychotic BD	−0.77	0.445	1	−82.4	(106.8)	0.06	0.95	1	8.3	(132.2)
Left amygdala
Non-psychotic BD	−1.19	0.244	0.732	−85.6	(71.8)	−0.94	0.359	1	−74.2	(79.4)
Psychotic BD	−1.95	0.058	0.168	−107.3	(55.1)	−2.69	0.010	0.030	−175.5	(65.4)
Right amygdala
Non-psychotic BD	−0.27	0.791	1	−22.6	(83.0)	0.30	0.764	1	27.5	(90.8)
Psychotic BD	−1.15	0.257	0.771	−72.8	(63.4)	−2.26	0.029	0.087	−168.8	(74.9)
Left lateral ventricle
Non-psychotic BD	0.23	0.871	1	389.3	(1162.1)	−0.29	0.772	1	−531.5	(1818.8)
Psychotic BD	−1.65	0.107	0.321	−2172.7	(1319.6)	−0.76	0.442	1	−1288.1	(1661.5)
Right lateral ventricle
Non-psychotic BD	0.90	0.377	1	1303.2	(1450.6)	0.52	0.610	1	827.9	(1604.6)
Psychotic BD	−0.77	0.447	1	−986.2	(1286.2)	−0.29	0.776	1	−456.3	(1590.9)

Severe OCs, Severe hypoxia-related obstetric complications; BD, bipolar disorder; adj p, adjusted p values after Bonferroni correction; s.e., standard error.

^aLinear regression analyses controlled for effects of age, sex and intracranial volume within each diagnostic group.