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Retigabine or ICA-27243 impairs motor coordination. Rats administered with retigabine (A) and ICA-27243 (B) at 10, 30 or 100 mg/kg were tested for time spent on the rotarod 30 min after the dosing. Each data was presented as the mean ± S.E.M. of determinations in 6 rats. *p < 0.05 vs vehicle.
