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. 2014 Feb 21;10:15. doi: 10.1186/1744-8069-10-15

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Copyright © 2014 Hayashi et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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XE-991 reverses retigabine-induced anticonvulsant activity. (A) The maximal electronic seizures (MES) test was used to determine tonic extensor convulsions in rats exposed to retigabine at 1–100 mg/kg. (B) Retigabine (20 mg/kg)-exposed rats with or without XE-991 (80 μg/site) were tested for anticonvulsant activity via the MES test. Retigabine and XE-991 was administered 30 min and 20 min prior to the MES test, respectively. Numbers on top of each column represent the number of rats in which tonic extensor convulsions were inhibited out of total number (N = 10 and 8, respectively).