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XE-991 reversed retigabine-induced analgesia in the inflammatory pain model. Inflammatory pain was induced by CFA injection, and 18 hr after CFA injection, PWL was measured in retigabine (20 mg/kg)-exposed rats with or without XE-991 (80 μg/site). Retigabine and XE-991 was administered 30 min and 20 min prior to the behavior test, respectively. Each data was presented as the mean ± S.E.M. in 5 to 6 rats. *p < 0.05; N.S., not significant.
