Table 1.
Summary of the significant pERK1, pERK2, P-p90RSK and c-Fos findings in mouse prefrontal cortex and striatum following aripiprazole and quetiapine treatment over 24 hours
| APD | Brain region | Protein | 20 min | 60 min | 240 min | 480 min | 24/24 |
|---|---|---|---|---|---|---|---|
| Aripiprazole |
Prefrontal cortex |
pERK1 |
↓ |
↑ |
↓ |
- |
- |
| pERK2 |
↓ |
↑ |
- |
- |
- |
||
| P-p90RSK |
- |
- |
- |
- |
- |
||
| c-Fos |
- |
↑ |
- |
- |
- |
||
| Striatum |
pERK1 |
- |
- |
- |
- |
- |
|
| pERK2 |
- |
- |
- |
- |
- |
||
| P-p90RSK |
- |
- |
- |
- |
- |
||
| c-Fos |
↑ |
↑ |
- |
- |
- |
||
| Quetiapine |
Prefrontal cortex |
pERK1 |
- |
- |
- |
- |
- |
| pERK2 |
- |
- |
- |
- |
- |
||
| P-p90RSK |
↓ |
- |
- |
- |
- |
||
| c-Fos |
- |
- |
↑ |
- |
- |
||
| Striatum |
pERK1 |
- |
- |
↑ |
- |
- |
|
| pERK2 |
- |
- |
- |
- |
- |
||
| P-p90RSK |
↓ |
↓ |
- |
- |
- |
||
| c-Fos | - | - | ↑ | - | - |
↓ = significantly decreased protein phosphorylation.
↑ = significantly increased protein phosphorylation.
- = no significant change.
APD = antipsychotic drug, min = minutes.