Table 1.
Clinical and demographic characteristics of patients with multidrug resistant Acinetobacter baumannii pneumonia treated with colistin or tigecycline
| Characteristics | Total N = 294 | Colistin N = 119 | Tigecycline N = 175 | p - value |
|---|---|---|---|---|
| Age |
63.8 (18.5) |
63.7 (19.5) |
63.8 (17.9) |
.95 |
| Male |
198 (67.3) |
86 (72.3) |
112 (64) |
.16 |
| APACHE II score |
22.5 (9.1) |
22.8 (9.3) |
22.3 (8.9) |
.68 |
| Length of hospital stay before enrollment |
32.0 (36.9) |
33.2 (45.9) |
31.2 (29.4) |
.64 |
| Underlying diseases |
|
|
|
|
| Cardiovascular disease |
47 (16.0) |
17 (14.3) |
30 (17.1) |
.63 |
| Diabetes mellitus |
84 (28.6) |
33 (27.7) |
51 (29.1) |
.90 |
| Insulin use |
63 (21.4) |
28 (23.5) |
35 (20) |
.47 |
| Chronic kidney disease |
59 (20.1) |
28 (23.5) |
31 (17.7) |
.24 |
| Liver cirrhosis |
13 (4.4) |
4 (3.4) |
9 (5.1) |
.57 |
| Chronic pulmonary disease |
30 (10.2) |
15 (12.6) |
15 (8.6) |
.33 |
| Malignancy |
36 (12.2) |
34 (28.6) |
2 (1.1) |
<.001 |
| Autoimmune |
16 (5.4) |
5 (4.2) |
11 (6.3) |
.60 |
| Operation history |
140 (47.6) |
51 (42.9) |
89 (50.9) |
.19 |
| Combination therapy |
|
|
|
|
| Aminoglycoside |
4 (1.4) |
1 (0.8) |
3 (1.7) |
.65 |
| Carbapenem |
34 (11.6) |
15 (12.6) |
19 (10.9) |
.65 |
| Sulbactam |
10 (3.4) |
2 (1.7) |
8 (4.6) |
.21 |
| Baseline creatinine (mg/dL) |
1.75 (1.47) |
1.66 (1.43) |
1.81 (1.50) |
.40 |
| Duration of treatment |
13.7 (12.5) |
14.6 (13.7) |
13.1 (11.6) |
.31 |
| Follow-up duration | 32.4 (31.5) | 33.1 (30.9) | 31.9 (32.0) | .75 |
APACHE II, acute physiology and chronic health evaluation II.