Table 2. Summary of MPER+ serum Ab responses to various Env protein/MPER peptide immunogens in MHC haplotype congenic BALB mice.
| Immunization Regimen | MPER+ (2F5 nominal epitope-specific) serum Ig endpoint titer ranges1 | ||||
|---|---|---|---|---|---|
|
|
|
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| Route | Prime | Boosts (x4) | BALB.B (H-2b) | BALB/c (H-2d) | |
|
|
|
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| IP | DP178Q16L + oCpG | DP178Q16L + oCpG | - | ++ | |
| IM | Env (JRFL) + oCpG | DP178Q16L + oCpG | - | ++ → +++ | |
| IP | Env (JRFL) + oCpG | DP178Q16L + oCpG | - | +++ | |
| IP | GTH1-MPER 656 + oCpG | GTH1-MPER 656 + oCpG | - | +++ | |
| IP | Env (JRFL) + oCpG | GTH1-MPER 656 + oCpG | - | +++ | |
| IP | Liposomes (with GTH1-MPER 656/MPLA)+oCpG | Liposomes (with GTH1-MPER 656/MPLA) + oCpG | - → + | ++++ | |
| IM | Env (JRFL) + oCpG | Liposomes (with GTH1-MPER 656/MPLA) + oCpG | - → +/- | +++ → +++++ | |
| IP | Env (JRFL) + oCpG | Liposomes (with GTH1-MPER 656/MPLA) + oCpG | - → + | ++++ | |
1
Data shown was calculated and is denoted the same way as shown for Table 1, and was calculated from two independent experiments.