Table 7.
Comparison of the clinical characteristics of chronic hepatitis C patients with (A2–3) or without (A0–1) severe hepatic inflammation
| |
|
A0-A1 |
|
A2-A3 |
|
|
|
|---|---|---|---|---|---|---|---|
| |
|
n = 32 |
|
n = 45 |
|
|
|
| Factor | Mean or number | Maximum | Minimum | Mean or number | Maximum | Minimum | P value * |
| Age (years) |
51.9 |
70 |
20 |
59.1 |
76 |
24 |
0.039 |
| Sex (male/female) |
14/18 |
|
|
17/28 |
|
|
0.598 |
| Body mass index (kg/m2) |
23.1 |
30.1 |
16.4 |
23.7 |
32.2 |
17.8 |
0.694 |
| Platelets (×104/μl) |
21.3 |
41.9 |
11.1 |
15.8 |
39.7 |
5.4 |
<0.001 |
| Total cholesterol (mg/dl) |
180.9 |
295 |
101 |
163.4 |
251 |
84 |
0.122 |
| Albumin (g/dl) |
4.4 |
5.1 |
3.3 |
4.2 |
4.9 |
2.9 |
0.003 |
| ALT (IU/l) |
42.2 |
165 |
13 |
80.3 |
244 |
14 |
0.003 |
| γ-GTP (IU/l) |
32.3 |
114 |
12 |
62.8 |
468 |
12 |
0.006 |
| Diabetes (absent/present) |
6/26 |
|
|
11/34 |
|
|
0.553 |
| Fasting plasma glucose (mg/dl) |
97.8 |
196 |
75 |
96.5 |
176 |
72 |
0.983 |
| Hemoglobin A1c (%) |
5.4 (n = 31) |
7.6 |
4.6 |
5.4 (n = 44) |
7.1 |
4.7 |
0.643 |
| Leptin (ng/ml) |
7.2 |
21.8 |
1 |
7.8 |
20.7 |
1.1 |
0.247 |
| Adiponectin (ng/ml) |
8.9 |
27.3 |
1.1 |
9 |
26.7 |
1.7 |
0.463 |
| Resistin (ng/ml) |
8.6 |
27.6 |
2.5 |
8.5 |
19.7 |
3 |
0.687 |
| AIM (μg/ml) |
1.17 |
4.56 |
0.41 |
1.54 |
6.44 |
0.76 |
0.001 |
| Hyaluronic acid (ng/ml) | 58.8 | 10.0 | 292.7 | 123.4 (n = 43) | 12.1 | 636.0 | 0.001 |
*Calculated by Chi-square test for categorical variables or Mann–Whitney U test for continuous variables.
ALT, alanine aminotransferase; γGTP, γ-glutamyl transpeptidase; HOMA-IR, homeostasis model assessment-insulin resistance; AIM, apoptosis inhibitor of macrophage.