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Model of Xenopus rhodopsin transcriptional activation. Nrl binds to the rhodopsin promoter via a highly conserved NRE site (TGCTGAnnC) that is immediately upstream of the TATA binding site. Crx binds independently to two adjacent sites (G/CTTA). This combination synergistically activates transcription with each Crx contributing equally to the overall activity. The Ret1 site (CCAATTA) mediates Rax protein binding to stimulate transcription.
