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. 2014 Feb 5;13:23. doi: 10.1186/1476-4598-13-23

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Copyright © 2014 Cardani et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Preservation of tight junction and adherence junction integrity by BLF501 in mice repeatedly injected with DXR and 5FU, stabilizing ZO-1 and beta-catenin expression and distribution. ZO-1 immunofluorescence assay: (A) UNTR, untreated; (B) DXR + 5-FU; (C) BLF501 25 μg/kg; (D) DXR + 5-FU + BLF501 2.5 μg/kg; (E) DXR + 5-FU + BLF501 25 μg/kg. Magnification 60X. Immunohistochemical analysis of beta-catenin: (F) UNTR, untreated; (G) DXR + 5-FU; (H) DXR + 5-FU + BLF501 2.5 μg/kg; (I) DXR + 5-FU + BLF501 25 μg/kg; (J) BLF501 25 μg/kg. Magnification 40X. Western blot assay for epithelial damage markers caspase 3 (K), ERM complex (L), and GAPDH as housekeeping protein (M). Experiments were performed in triplicate.