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. 2014 Feb 5;13:23. doi: 10.1186/1476-4598-13-23

Table 1.

Summary of in vivo treatments

I . BLF501 action/single DXR injection
Mouse strain
 Group
 Mice/Group
 DXR
 BLF501 25 μg/kg
 Sacrifice 48 h
 Sacrifice 72 h
 BrdU injection
BALB/C
 UNTR
 N = 7
 -
 -
 -
 N = 7
 +
DXR
 N = 14 (7 + 7)
 +
 -
 N = 7
 N = 7
 +
DXR +BLF501 25 μg/kg
 N = 14 (7 + 7)
 +
 +
 N = 7
 N = 7
 +
BLF501 25 μg/kg
 N = 14 (7 + 7)
 -
 +
 N = 7
 N = 7
 +
Mouse strain
 Group
 Mice/Group
 DXR
 BLF501 25 μg/kg
 Sacrifice 48 h
 Sacrifice 72 h
 BrdU injection
C57 SGLT-1 -/-
 UNTR
 N = 7
 -
 -
 -
 N = 7
 +
 
 DXR
 N = 7
 +
 -
 -
 N = 7
 +
 
 DXR +BLF501 25 μg/kg
 N = 7
 +
 +
 -
 N = 7
 +
II . BLF501 action/repeated DXR plus 5-FU injections
Mouse strain
 Group
 Mice/Group
 DXR +5-FU
 BLF501 0.25 μg/kg
 BLF501 2.5 μg/kg
 BLF501 25 μg/kg
 Treatment days
 Sacrifice day
BALB/C
 UNTR
 N = 7
 -
 -
  
  
 -
 Day 19
DXR + 5FU
 N = 7
 +
 -
  
  
 Days 1, 8 and 15
DXR + 5FU +BLF501 0.25 μg/kg
 N = 7
 +
 +
  
  
DXR + 5FU +BLF501 2.5 μg/kg
 N = 7
 +
 -
 +
  
DXR + 5FU +BLF501 25 μg/kg
 N = 7
 +
 -
 -
 +
BLF501 25 μg/kg
 N = 7
 -
 -
 -
 +
III . BLF501/DXR interaction
Mouse strain
 Group
 Mice/Group
 DXR
 BLF501 25 μg/kg
 Treatment days
 Sacrifice day
SKH-1
 UNTR
 N = 8
 -
 -
 -
 Day 26
DXR
 N = 8
 +
 -
 Days 7, 14 and 21 after cell injection
DXR +BLF501 25 μg/kg
 N = 8
 +
 +
  BLF501 N = 8 - +