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. 2014 Mar 1;25(5):688–701. doi: 10.1091/mbc.E13-04-0219

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© 2014 Vinet et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 9: — Proposed model for initiation of the cAMP pathway by coronin A. In response to nutrient deprivation, cells secrete factors that bind to cell surface receptors and subsequently activate the Gα2βγ-dependent pathway upon cAMP binding (cAMP relay). The data presented in this article suggest a role for coronin A immediately downstream of the receptor(s) activated by secreted factors and upstream of the activation of the cAMP relay. Coronin A could also mediate the expression of the developmental genes via a cAMP-independent pathway, which would then be necessary for the amplification of the cAMP relay and thus aggregation.