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. 2014 Feb 27;10(2):e1003490. doi: 10.1371/journal.pcbi.1003490

Figure 1. A. Schematic description of the circuits discussed in the paper.

Figure 1

NM1: direct regulation; NM2: open motif in which the microRNA regulates only the transcription factor; NM3: open motif in which the microRNA regulates only the target; NM4: Open motif in which the microRNA regulates both the TF and the target but the TF-target link is missing; NM5, open motif in which two different microRNAs regulate separately the TF and the target. In the box we show the activactory micFFL whose deterministic and stochastic behavior we studied in the paper. B. Schematic view of the general miRNA controlled Feed Forward Loops (combining both activactory and repressive TF-target interactions) mined in the bioinformatic analysis discussed in the paper. C. Schematic description of the chemical reactions which must be taken into account to describe the miRNA-mediated feedforward loop with a miRNA-target titrative interaction.