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. 2013 Dec 10;8:205. doi: 10.1186/1746-1596-8-205

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Copyright © 2013 Gao et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Immunohistochemical demonstration of claudins protein and E-cadherin expression in human gastric cancer and adjacent tissue. Claudins and E-cadherin were expressed in the cell membrane. (A), high E-Cadherin expression was detected in tissue adjacent to human gastric cancer compared with low E-Cadherin expression in human gastric cancer tissue (B) (400×) (C), claudin-10 was highly expressed in epithelial cells adjacent to gastric cancer but was expressed at low levels in cancer tissue itself (D). (E), the low expression of claudin-14 in tissue adjacent to human gastric cancer compared to strong expression of claudin-14 in human gastric cancer tissue (F). (G), high claudin-17 expression was detected in tissue adjacent to human gastric cancer compared with low claudin-17 expression in human gastric cancer tissue (H) (400×).