Table 2.
Expression of CLAUDIN-10, CLAUDIN-14, CLAUDIN-17 and clinic pathological characteristics in gastric cancer patients
| Item | n | CLAUDIN-10(+) | CLAUDIN-10(-) | P | n | CLAUDIN-14(+) | CLAUDIN-14(-) | P | n | CLAUDIN-17(+) | CLAUDIN-17(-) | P |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gastric cancer tissue |
50 |
12 |
38 |
<0.01 |
50 |
29 |
21 |
<0.01 |
50 |
9 |
41 |
<0.01 |
| Adjacent tissue |
50 |
36 |
14 |
|
50 |
12 |
38 |
|
50 |
35 |
15 |
|
| Gender |
|
|
|
|
|
|
|
|
|
|
|
|
| Male |
34 |
8 |
28 |
0.664* |
34 |
20 |
14 |
0.355* |
34 |
7 |
27 |
0.475* |
| Female |
16 |
4 |
12 |
|
16 |
9 |
7 |
|
16 |
2 |
14 |
|
| Age(year) |
|
|
|
|
|
|
|
|
|
|
|
|
| ≤60 |
26 |
7 |
19 |
1.000* |
26 |
15 |
11 |
1.000* |
26 |
4 |
22 |
0.677* |
| >60 |
24 |
5 |
19 |
|
24 |
14 |
10 |
|
24 |
5 |
19 |
|
| Histological grade |
|
|
|
|
|
|
|
|
|
|
|
|
| Well –differentiated |
14 |
4 |
10 |
1.000* |
14 |
6 |
8 |
0.641* |
14 |
3 |
11 |
1.000* |
| Moderately differentiated |
25 |
7 |
18 |
|
25 |
15 |
10 |
|
25 |
5 |
20 |
|
| Poor differentiated |
11 |
1 |
10 |
|
11 |
8 |
3 |
|
11 |
1 |
10 |
|
| Lymph node metastasis |
|
|
|
|
|
|
|
|
|
|
|
|
| + |
24 |
3 |
21 |
<0.01 |
24 |
18 |
6 |
<0.05 |
24 |
2 |
22 |
<0.05 |
| - |
26 |
9 |
17 |
|
26 |
11 |
15 |
|
26 |
7 |
19 |
|
| E-cadherin |
|
|
|
|
|
|
|
|
|
|
|
|
| + |
16 |
9 |
7 |
<0.0 |
|
7 |
9 |
|
16 |
6 |
10 |
<0.01 |
| - |
|
3 |
|
1 |
16 |
22 |
12 |
<0.05 |
34 |
3 |
31 |
|
| Ki67 |
|
|
31 |
|
|
|
|
|
|
|
|
|
| + |
|
5 |
|
|
34 |
9 |
8 |
|
17 |
4 |
13 |
0.633* |
| - |
34 |
7 |
12 |
0.464* |
|
|
13 |
|
|
5 |
28 |
|
| |
|
|
26 |
|
|
|
|
1.000* |
|
|
|
|
| |
17 |
|
|
|
17 |
|
|
|
|
|
|
|
| 33 | 33 | 20 | 33 |
*No statistical significance.