Table 1.
Expression of androgen receptor, p53, EGFR, and Ki67 molecules in five subtypes of breast cancer
| HHR n (%) | LHR-HTH2 n (%) | LHR-LTH2 n (%) | NHR-HTH2 n (%) | NHR-LTH2 n (%) | P-value | |
|---|---|---|---|---|---|---|
| EGFR | 0.381 | |||||
| Positive | 21 (52.5) | 20 (58.8) | 48 (46.2) | 21 (60.0) | 17 (63.0) | |
| Negative | 19 (47.5) | 14 (41.2) | 56 (53.8) | 14 (40.0) | 10 (37.0) | |
| Ki67 | 0.077 | |||||
| Positive | 17 (42.5) | 22 (64.7) | 49 (47.1) | 17 (48.6) | 19 (70.4) | |
| Negative | 23 (57.5) | 12 (35.3) | 55 (52.9) | 18 (51.4) | 8 (29.6) | |
| AR* | <0.001 | |||||
| Positive | 29 (76.3) | 17 (51.5) | 45 (45.0) | 11 (35.5) | 4 (14.8) | |
| Negative | 9 (23.7) | 16 (48.5) | 55 (55.0) | 20 (64.5) | 23 (85.2) | |
| p53** | 0.164 | |||||
| Positive | 24 (63.2) | 22 (66.7) | 48 (49.0) | 22 (68.8) | 14 (51.9) | |
| Negative | 14 (36.8) | 11 (33.3) | 50 (51.0) | 10 (31.2) | 13 (48.1) |
Notes: For Ki67, >13% tumor cell nuclei staining was defined as positive; for AR and p53, >10% tumor cell nuclei staining was defined as positive
*
AR status could not be obtained for 11 patients
**
p53 status could not be obtained for 12 patients.
Abbreviations: AR, androgen receptor; EGFR, epidermal growth factor receptor; HHR, high hormone receptor expression; LHR, low hormone receptor expression; NHR, negative hormone receptor expression; HTH2, high total HER2 load; LTH2, low total HER2 load.