Table 2.

Multivariate analysis by 5-year disease-free survival

Items	Hazard ratio (95% CI)	P-value
Overall subtypes		0.028
HHR*	Reference	–
LHR-LTH2	1.984 (0.866–4.543)	0.105
LHR-HTH2	2.824 (1.148–6.947)	0.024
NHR-LTH2	2.190 (0.851–5.637)	0.104
NHR-HTH2	3.853 (1.605–9.252)	0.003
EGFR	1.418 (0.901–2.232)	0.131
Ki67	1.149 (0.719–1.836)	0.56
Tumor size	1.518 (1.042–2.212)	0.03
Tumor grade	2.626 (1.719–4.011)	<0.001
Lymph nodes	3.605 (2.073–6.270)	<0.001

Note:

^*HHR subgroup used as reference state in multivariate analysis.

Abbreviations: EGFR, epidermal growth factor receptor; CI, confidence interval; HHR, high hormone receptor expression; LHR, low hormone receptor expression; NHR, negative hormone receptor expression; HTH2, high total HER2 load; LTH2, low total HER2 load.