Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Feb 27;10(2):e1004168. doi: 10.1371/journal.pgen.1004168

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Garay et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Cumulative frequencies of the relative lifespan of most viable knockout strains (black circles, n = 3,878) and replicates of the WT (gray crosses, n = 414). Colored symbols correspond to selected knockouts (right panel). Inset shows the fraction of significant short- (magenta) and long-lived phenotypes (cyan) (5% FDR). Short-CLS phenotypes with reduced growth capacity (G<0.95) were filtered-out from subsequent analyses (see Figure S5). (B) CLS-specific gene groups and pathways; plot shows the median relative lifespan () of genes annotated in the same GO term, which was compared in each case to the median lifespan of the entire data set. Labels at the vertical axis show representative enriched GO categories (p<0.05, Wilcoxon rank sum test). The radius of each circle indicates the number of measured gene knockouts within the GO group, the minimum being five (de novo IMP biosynthesis) and the maximum 39 (nucleolus); colors were arbitrarily assigned to similar functional categories. Data set includes 3,286 strains that have no marked defect in growth (G>0.95).

Inline graphic — (A) Cumulative frequencies of the relative lifespan of most viable knockout strains (black circles, n = 3,878) and replicates of the WT (gray crosses, n = 414). Colored symbols correspond to selected knockouts (right panel). Inset shows the fraction of significant short- (magenta) and long-lived phenotypes (cyan) (5% FDR). Short-CLS phenotypes with reduced growth capacity (G<0.95) were filtered-out from subsequent analyses (see Figure S5). (B) CLS-specific gene groups and pathways; plot shows the median relative lifespan () of genes annotated in the same GO term, which was compared in each case to the median lifespan of the entire data set. Labels at the vertical axis show representative enriched GO categories (p<0.05, Wilcoxon rank sum test). The radius of each circle indicates the number of measured gene knockouts within the GO group, the minimum being five (de novo IMP biosynthesis) and the maximum 39 (nucleolus); colors were arbitrarily assigned to similar functional categories. Data set includes 3,286 strains that have no marked defect in growth (G>0.95).