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In silico 10-fold knockdown of Itgb2 modulates MMP-9. Plots of simulated concentrations of A. MMP-9, B. lung weight, C. MMP activity, and D. TIMP-1 in response to a 10-fold knockdown of Itgb2 expression. Baseline (without knockdown), blue; knockdown, red. The time point shown here is 5 months and the conditions are high-dose CS.
