Table 1.
Number of animals used to capture each measured endpoint (gene expression, MMP activity, MMP-9 and TIMP-1 abundance, lung weight) per condition (dose and time point).
| EXPOSURE TIME | 1 DAY | 7 DAYS | 1 MONTH | 5 MONTHS | 5 MONTHS + 2 MONTHS PE | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SMOKE EXPOSURE GROUPS | SHAM | LOW | HIGH | SHAM | LOW | HIGH | SHAM | LOW | HIGH | SHAM | LOW | HIGH | SHAM | HIGH |
| Gene expression | 8 | 7 | 8 | 8 | 8 | 8 | 7 | 7 | 8 | 8 | 8 | 8 | 8 | 8 |
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| MMP activity | ND | 9 | 9 | 10 | 10 | 8 | 10 | 9 | 10 | 10 | 10 | 10 | 5 | 9 |
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| MMP-9 | ND | 10 | 10 | 10 | 10 | 10 | 10 | 9 | 9 | 10 | 10 | 10 | 8 | 10 |
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| TIMP-1 | ND | 10 | 10 | 10 | 10 | 10 | 10 | 9 | 9 | 9 | 9 | 8 | 8 | 10 |
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| Lung weight | 10 | 10 | 10 | 10 | 9 | 10 | 10 | 10 | 10 | 18 | ND | 24 | 20 | 20 |
Note: ND, not determined.