Table 2.

Key molecular drivers identified by REFS™ for the four measured endpoints.

GENE SYMBOL	NAME	MMP-9	MMP ACTIVITY	TIMP-1	LUNG WEIGHT
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	×
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	×
Cyba	cytochrome b-245, alpha polypeptide	×			×
Rnh1	ribonuclease/angiogenin inhibitor 1	×			×
Ctsz	cathepsin Z	×			×
Hal	histidine ammonia lyase	×
Gusb	glucuronidase, beta	×			×
Itgb2	integrin beta 2	×
Fuca1	fucosidase, alpha-L-1, tissue	×		×	×
Psmd8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	×
Clec7a	C-type lectin domain family 7, member a	×
Itgax	integrin alpha X	×
Nceh1	arylacetamide deacetylase-like 1		×
Macf1	microtubule-actin crosslinking factor 1		×
Ceacam1; Ceacam2	carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 2		×
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2		×
Ubxn2a	UBX domain protein 2A		×
Pltp	phospholipid transfer protein		×
Kif5b	kinesin family member 5B		×
Gstp1	glutathione S-transferase, pi 1			×
Zranb1	zinc finger, RAN-binding domain containing 1			×
Pcf11	cleavage and polyadenylation factor subunit homolog (S. cerevisiae)			×
Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1				×
Npy	neuropeptide Y				×
Trem2	triggering receptor expressed on myeloid cells 2				×
Hvcn1	hydrogen voltage-gated channel 1				×
Orm1	orosomucoid 1				×
Ctsb	cathepsin B				×
Msr1	macrophage scavenger receptor 1				×
Pla2g2d	phospholipase A2, group IID				×
Atp6v0c	ATPase, H+ transporting, lysosomal V0 subunit C				×
Hpse	heparanase				×