. Author manuscript; available in PMC: 2014 Feb 27.

Published in final edited form as: J Gastroenterol Hepatol. 2013 Aug;28(0 1):112–115. doi: 10.1111/jgh.12023

Table 1.

HSCs in HCV-mediated liver fibrosis

HCV and its proteins	HSCs	References
HCV	Induces liver injury, which activates HSCs	^27,28
	Engulfs ABs through phagocytosis triggers a profibrogenic response in HSCs	^20,21
E2	Upregulates matrix aetalloproteinase-2 expression, increasing degradation of the normal hepatic extracellular matrix in HSCs	²⁵
Core	Induces fibrogenic actions and stimulates intracellular signaling pathway in HSCs	^26,29
NS3-NS5	Induces pro-inflammatory cytokines in HSCs	²⁶

HCV, hepatitis C virus; HSC, hepatic stellate cell.