Figure 1. Effectiveness of the L-Ca channel blocker nifedipine and the local anesthetic lignocaine in inhibiting lymph flow in the rat hind limb.

Foot to groin lymph transit times were measured using the marker dye India ink injected into a hind foot of each anaesthetized rat under control conditions or when the corresponding hind limb was covered with the topical pharmacological agent. The pharmacological agents all significantly increased transit times compared to control. Asterisks indicate significant differences with respect to control obtained by one-way ANOVA followed by Holm-Sidak's multiple comparison test (**** P<0.0001; n = 11, 10 & 6 for control, nifedipine & lignocaine respectively).